1 |
Management and Outcome of Young Women (≤40 Years) with Breast Cancer in Switzerland
|
|
|
|
In: Cancers; Volume 14; Issue 5; Pages: 1328 (2022)
|
|
Abstract:
Background: An increase in breast cancer (BC) incidence in young women (YW) as well as disparities in BC outcomes have been reported in Switzerland. We sought to evaluate treatment and outcome differences among YW with BC (YWBC). Methods: YW diagnosed with stage I-III BC between 2000–2014 were identified through nine cancer registries. Concordance with international guidelines was assessed for 12 items covering clinical/surgical management, combined in a quality-of-care score. We compared score and survival outcome between the two linguistic-geographic regions of Switzerland (Swiss-Latin and Swiss-German) and evaluated the impact of quality-of-care on survival. Results: A total of 2477 women were included. The median age was 37.3 years (IQR 34.0–39.4 years), with 50.3% having stage II BC and 70.3% having estrogen receptor positive tumors. The mean quality-of-care score was higher in the Latin region compared to the German region (86.0% vs. 83.2%, p < 0.0005). Similarly, 5- and 10-year overall survival rates were higher in the Latin compared to the German region (92.3% vs. 90.2%, p = 0.0593, and 84.3% vs. 81.5%, p = 0.0025, respectively). There was no difference in survival according to the score. In the univariate analysis, women in the Latin region had a 28% lower mortality risk compared to women in the German region (hazard ratio 0.72; 95% CI 0.59–0.89). In the multivariable analysis, only stage, differentiation, tumor subtype and treatment period remained independently associated with survival. Conclusions: We identified geographic disparities in the treatment and outcome of YWBC in Switzerland. National guidelines for YWBC should be implemented to standardize treatment. Awareness should be raised among YW and clinicians that BC does not discriminate by age.
|
|
Keyword:
breast cancer; management; outcome; Switzerland; young women
|
|
URL: https://doi.org/10.3390/cancers14051328
|
|
BASE
|
|
Hide details
|
|
2 |
Changing from Visibility to Invisibility—An Intersectional Perspective on Mixedness in Switzerland and Morocco
|
|
|
|
In: Genealogy; Volume 6; Issue 2; Pages: 30 (2022)
|
|
BASE
|
|
Show details
|
|
3 |
Gegen die Öffentlichkeit: Alternative Nachrichtenmedien im deutschsprachigen Raum
|
|
Schwaiger, Lisa. - : transcript Verlag, 2022. : DEU, 2022. : Bielefeld, 2022
|
|
In: 46 ; Digitale Gesellschaft ; 327 (2022)
|
|
BASE
|
|
Show details
|
|
4 |
Facilitators and barriers of women's participation in HIV clinical research in Switzerland: A qualitative study.
|
|
|
|
In: HIV medicine, vol. 23, no. 4, pp. 441-447 (2022)
|
|
BASE
|
|
Show details
|
|
5 |
Talking about chronic pain in family settings: a glimpse of older persons' everyday realities.
|
|
|
|
In: BMC geriatrics, vol. 22, no. 1, pp. 358 (2022)
|
|
BASE
|
|
Show details
|
|
6 |
Healthcare stakeholders' perspective on barriers to integrated care in Switzerland: Results from the open-ended question of a nationwide survey.
|
|
|
|
In: Journal of evaluation in clinical practice, vol. 28, no. 1, pp. 129-134 (2022)
|
|
BASE
|
|
Show details
|
|
|
|